Anti Obesity

What do we mean by being Healthy? How do we know our body or mind is enjoying a state of Health? One has an awareness of the healthiness of one’s diet and lifestyle, but still changing according to the western modern culture , constantly  bombarded  by  fast  food at every  corner,  spend  countless  hours  in  front  of  the television  being sedentary. And, as  a result of all of this, there exists a generation that is out-of-shape, overweight and obese.

Obesity is a common, serious and growing problem.Obesity is a condition where a person has accumulated so much body fat that it might have a negative effect on their health. If a person’s bodyweight is at least 20% higher than it should be, he or she is considered obese. Overweight or obese patients who have not lost an average of 1 lb (0.5 kg) per week after at least six months on a balanced low-calorie diet, including increased exercise and behavior therapy, may be considered candidates for weight loss drugs.To screen for overweight and obesity, doctors measure BMI using calculations that depend on whether you are a child or an adult. A healthy weight for adults is usually when your BMI is 18.5 to less than 25.

What causes otal cause of obesity is an energy imbalance between calories consumed and cabesity ???

The fundamenlories expended. Globally, there has been:

• an increased intake of energy-dense foods that are high in fat; and
• an increase in physical inactivity due to the increasingly sedentary nature of many forms of work, changing modes of transportation, and increasing urbanization.

Causes of obesity

At individual level, the combination of excessive food energy intake and lack of physical activity is thought to explain most of obesity causes. In limited cases, obesity is due to genetic factors, medical reasons, or psychiatric illness.On the other hand, increasing rates of obesity at a societal level are felt to be due to easily accessible and palatable diet, increased reliance on cars, and mechanized manufacturing. A 2006 review identified ten other possible contributors to the recent increase of obesity including insufficient sleep, endocrine disruptors, decreased variability in ambient temperature, decreased rates of smoking, as smoking suppresses appetite, increased use of medications that can cause weight gain (e.g., atypical antipsychotics), proportional increases in ethnic and age groups that tend to be heavier, pregnancy at a later age (which may cause susceptibility to obesity in children), epigenetic risk factors passed on generationally, natural selection for higher BMI, and assortative mating leading to increased concentration of obesity risk factors.

 Diet

Obesity rates in the US (1971–2000) increased from 14.5% to 30.9%.During the same period, there was an increase in the average amount of food consumed (average increase for women 335 and 168 cal./day). Most of this extra food energy was due to the increase in carbohydrates rather than fat consumption.

Sedentary lifestyle

There is a large shift toward less physically demanding work worldwide. Currently, at least 60% of the world’s population gets insufficient exercise, due to increased use of mechanized transportation and a greater prevalence of labor-saving technology at home.The WHO indicates people worldwide are taking up less active recreational pursuits. In both children and adults, there is an association between television viewing time and the risk of obesity.

Genetics

Like many other medical conditions, obesity is the result of interplay between genetic and environmental factors. Polymorphisms in various genes controlling appetite and metabolism predispose to obesity when sufficient food energy is present. People with two copies of the FTO gene (fat mass and obesity associated gene) have been found on average to weigh 3–4 kg more and have a 1.67 fold greater risk of obesity compared to those without the risk allele. Some cases of obesity are related to single-gene mutations, e.g. melano-cortin-4 receptor (MC4R) gene, dopamine receptor D4 (DRD4), peroxisome proliferator-activated receptor y2 (PPARy2) or the leptin genes.

 Medical and psychiatric illness

Certain physical and mental illnesses and medications used to treat them can increase the risk of obesity. Medical illnesses that increase obesity risk include several rare genetic syndromes (Cohen syndrome), as well as some congenital or acquired conditions: hypothyroidism, growth hormone deficiency,and eating disorders (binge eating disorder and night eating syndrome).The risk of overweight and obesity is higher in patients with psychiatric disorders than in persons without psychiatric disorders.

Social determinants

Genetic influences are important to understand obesity. They cannot explain the current dramatic increase in obesity. Though, excess energy consumption than energy expenditure leads to obesity on individual basis. The cause of the shifts in these two factors on societal scale is much debated.In developing countries women of a high social class were less likely to be obese. No significant differences were seen among men of different social classes. In the developing world, population of high social classes had greater rates of obesity.Smoking has a significant effect on an individual’s weight. Those who quit smoking will gain an average of 4.4 kg (men) and 5.0 kg (women) over ten years. However, changing rates of smoking have little effect on the overall rates of obesity.

 Infectious agents

The study of infectious agent’s effect on metabolism is still in its early stages. The gut flora in obese and lean individuals can affect the metabolic potential. This apparent alteration is believed to confer a greater capacity to gain energy contributing to obesity. An association between viruses and obesity has been found in humans and several different animal species.

 Pathophysiology

Leptin and ghrelin are internal mediators that affect feeding and appetite. Ghrelin is produced by the stomach modulating short-term appetitive control (i.e., to eat when the stomach is empty and to stop when the stomach is stretched). Leptin is produced by white adipose tissue to signal fat storage reserves in the body and mediates long-term appetitive controls (i.e., to eat more when fat storages are low and less when fat storages are high). It plays a critical role in the regulation of body weight and energy balance by inhibiting food intake and stimulating energy expenditure.Although, administration of leptin may be effective in a small subset of obese individuals who are leptin deficient. Most obese individuals are thought to be leptin resistant and have been found to have high levels of leptin. This resistance is thought to explain in part why administration of leptin has not been shown to be effective in suppressing appetite in most obese people. Although leptin and ghrelin are produced peripherally, they control appetite through their actions on the central nervous system. Thus, a deficiency in leptin signaling either via leptin deficiency or leptin resistance leads to overfeeding and may account for some genetic and acquired forms of obesity.

In a well balanced body system,  nourishment to these tissues is provided through various micro channels. However, when it is aggravated, it leads to production of toxins in the body. These toxins are heavy and dense in nature and accumulate in weaker channels of the body, causing their blockage. In the case of an obese person, toxins accumulate in fat channels, thereby leading to an increase in the production of fat tissue. When the body produces more fat tissues, it causes an increase in weight.

The treatment for this condition focuses on cleansing of the micro channels through cleansing herbs so that excess weight can be reduced.

NutriCheer

MAKES FAT TO FIT

Following are the ingredients that will help you to remain fit

 White kidney bean extract-Extracts made from white kidney bean (Phaseolus vulgaris) are promoted for weight loss because they are thought to act as “starch blockers” by inhibiting the starch-digesting enzyme amylase which otherwise turns the starch you eat into absorbable sugar. White bean extract may be helpful for weight loss because the beans produce substances that interfere with an enzyme called amylase that is necessary for the breakdown of carbohydrates, which are one of the main sources of calories in many diets. If carbohydrates aren’t broken down into small enough units, your body can’t absorb them and can’t make use of the calories they provide. Absorbing fewer calories can help create the calorie deficit necessary for weight loss. Of course, this is most effective with complex carbohydrates, such as starches. Some sugars are already in small enough units that they can be readily absorbed by the intestines, so white bean extract wouldn’t affect their absorption. The fundamental theory of a white bean diet is that white kidney beans or their extracts have the potential to lower the glycemic index of certain high carbohydrate foods. The glycemic index of a food is an assessment of how quickly a carbohydrate increases blood sugar. Fibres that it contains reduces  formation of excess harmful cholesterol and also helps in reduction of post prandial plasma glucose level.

Black pepper extract–   Black pepper extract (piper nigrum), is the only product from piperine to obtain a patented status for its ability to increase the bioavailability of nutritional compounds.

Benefits :

· Weight Loss, Skin Health, Respiratory Relief,  Good for the Stomach,  Black pepper prevents body fat accumulation and new fat cell formation , boosts metabolism, helps burn calories quickly,  prevents oxidative stress induced in obesity

 Grape seed extract– It blocks conversion of triglycerides to fatty acids , ultimately reducing absorption of fats. Seeds from red and purple grapes contain high levels of vitamin E, flavonoids, linoleic acid and the powerful antioxidant compounds known as oligomeric proanthocyanidin complexes, or OPC’s, that may improve overall health and also prove to be an effective tool in fighting obesity and assisting in weight loss. Grape seed extracts contain potent antioxidant and anti-inflammatory properties that may improve overall health and also prove to be an effective tool in fighting obesity and assisting in weight loss.

Garcinia combogia extract– Garcinia cambogia is a plant native to Indonesia and is often referred to as gambooge. The plant bears a yellowish fruit that has a shape similar to a small pumpkin. G. cambogia may actually help to boost weight loss and acts as appetite suppressor too. Garcinia cambogia causes weight loss by oxidation of low-density lipoprotein oxidation. Low-density lipoprotein is considered as a  bad form of cholesterol, and oxidation is the process of burning energy.

Guggul extract–This extract can inhibit synthesis of cholesterol, speeds up excess excretion of cholesterol.It appears to promote weight loss by affecting your thyroid to stimulate metabolism and other key bodily actions like burning of calories and fats. In addition, the mechanism of action was the removal of adipocytes, or fat cells, via cell death.

Ginger extract-Ginger increases metabolism, stimulates circulation and excretion of toxins from the body. It lowers cholesterol by significantly reducing serum and hepatic cholesterol levels. Ginger acts as weight-loss aid that may suppress hunger,which makes cutting calories easier. It promotes the production of bile and may stimulate the production of gastric juices, both of which enhance digestion and make more energy available to burn.

Green tea extract– Green tea extract high in catechins decreases body weight, body fat and  is particularly beneficial for boosting metabolism during exercise. Green tea also contains another compound often used for its potential to boost the metabolism and promote weight loss – caffeine by way of fat oxidation and thermogenesis.

Glycyrrhiza glabra (Licorice)extract– It is  rich in flavonoids and is proven to exert anti-obesity action by regulating enzymatic activity involved in fat deposition and break down.

• Glabridinis a major flavonoid that prevents weight gain by suppressing abdominal fat accumulation, inhibiting development of fat tissue and lowering blood sugar levels.
• Glycyrrhiza chalconesalso come under the flavonoid group of licorice which demonstrate anti-obesity and lipid lowering effect.
• Glycyrrhizic acidobtained from licorice is found to decrease elevated leptin levels and decrease fat tissue produced as a result of high carbohydrate diet. Leptin is hunger hormone, suppression of which decreases appetite and food intake.
• 18β-glycyrrhetinic acidis another bioactive compound isolated from licorice. This compound reduces body weight, body fat and lipids exhibiting weight loss.It prevents development of fat cells and stimulates breakdown of fats in existing fat cells.

NutriCheer Antiobesity is the health supplement introduced by Dr. Madhukar Pharmaceuticals with the combination of all best ingredients to get rid of extra fats .

For More Information about Anti Obesity Health Supplements India Contact us at (+91) 7777038883 or Email us at – sales@madhukarpharma.com / sales1@madhukarpharma.com

Contact Details

Dr. Madhukar Pharmaceuticals (P) Ltd,

C-158, Amar Gyan Industrial Estate,

Khopat, Thane, West- 400301, India.

Mobile: +91 7777038883

Sales: sales@madhukarpharma.com / sales1@madhukarpharma.com